Tag Archives: skin bruising

Skin Manifestations of Inhaled Corticosteroids in COPD Patients: The effect of compliance

In the present report, easy bruising averaged 7.6% in the ICS group and 3.6% in the placebo group among all participants. These findings are roughly similar to those reported from previously published randomized controlled trials of ICS in COPD pa-tients, … Continue reading

Skin Manifestations of Inhaled Corticosteroids in COPD Patients: ICS therapy

Weaknesses of the above-cited older studies are that they were cross-sectional, nonrandomized surveys and that they relied on retrospective reporting of previous, as well as current, ICS use. Moreover, some subjects had received oral corticosteroids in variable amounts at least … Continue reading

Skin Manifestations of Inhaled Corticosteroids in COPD Patients: CFC

The relevance of these findings to potential cutaneous effects of other commonly used ICSs might be inferred from published data concerning the equi-systemic effects (ie, microgram dose producing equal systemic cortisol suppression) of six inhaled corticosteroid preparations. According to the … Continue reading

Skin Manifestations of Inhaled Corticosteroids in COPD Patients: Discussion

Easy Bruising and Acetylsalicylic Acid/Nonsteroidal Anti-inflammatory Drug Use Use of acetylsalicylic acid (ASA) or nonsteroidal anti-inflammatory drugs (NSAIDs) was reported by a slightly but significantly higher proportion of participants who also reported bruising (87.7%) than those who did not (78.8%; … Continue reading

Skin Manifestations of Inhaled Corticosteroids in COPD Patients: Slow Healing

Table 5 shows the results from logistic regression of reports of slow healing of any severity. The results indicate a significant treatment effect, mainly among the good compliers. Older age is also a significant predictor in all participants with a … Continue reading

Skin Manifestations of Inhaled Corticosteroids in COPD Patients: The ICS group

The percentages of participants reporting bruises a 25% of the time are shown in Figure 2. Again, clear and significant (p < 0.05) differences are found between the good compliers in the ICS group and all of the other subgroups, … Continue reading

Skin Manifestations of Inhaled Corticosteroids in COPD Patients: Easy Bruising

The adverse skin conditions that are well-recognized to result from or be associated with systemic corticosteroid use are listed in Table 2. Among these, rash, easy bruising, and slow healing differ between the groups, suggesting some systemic absorption. The reports … Continue reading

Skin Manifestations of Inhaled Corticosteroids in COPD Patients: Results

Differences in baseline characteristics between the ICS and placebo groups were assessed using t tests for continuous variables and x2 tests for categoric variables. Differences in the rates of new or worsening skin conditions were compared using the Wilcoxon rank-sum … Continue reading

Skin Manifestations of Inhaled Corticosteroids in COPD Patients: Assessment of Skin Changes

Every 6 months, beginning at the 18-month or 24-month visit, participants were administered a structured questionnaire in which they were asked whether, since their last clinic visit, they had experienced any skin rashes (and the percentage of time any skin … Continue reading

Skin Manifestations of Inhaled Corticosteroids in COPD Patients: Materials and Methods

Study Sample LHS II recruited 1,116 participants at 10 clinical centers in the United States and Canada. These were individuals who participated in LHS I (1,018 persons) or were screened for LHS I (98 persons), and were still smoking or … Continue reading

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