Tag Archives: 5-Lipoxygenase inhibition

Transcellular synthesis of cysteinyl-leukotrienes: From isolated cells to complex organ system (part 4)

Permanent ligation of the left descending artery resulted in significant mortality (65%) over the three days of observation, particularly during the first 24 h (45%). Pretreatment with BAY X1005 was life saving during the first 24 h after ligation (no … Continue reading

Transcellular synthesis of cysteinyl-leukotrienes: From isolated cells to complex organ system (part 3)

Male albino New Zealand rabbits, under anesthesia and artificial respiration, were opened on the left side of the thorax, and the small branch of the left anterior descending coronary artery was separated from the myocardial tissue for a length of … Continue reading

Transcellular synthesis of cysteinyl-leukotrienes: From isolated cells to complex organ system (part 2)

During the past five years we developed and characterized a model of spontaneously beating, isolated rabbit heart, perfused with purified human PMNL, showing that PMNL activation causes cys-LT formation through PMNL-endothelial cell transcellular synthesis, resulting in increased coronary resistance and … Continue reading

Transcellular synthesis of cysteinyl-leukotrienes: From isolated cells to complex organ system (part 1)

Cysteinyl-leukotriene (Cys-LT) formation either may proceed through activation of a single cell type, possessing both 5-lipoxygenase and leukotriene (LT) C4 synthase enzymatic activities (direct synthesis), or it may involve the participation of different cell types whereby donor cells (ie, polymorphonuclear … Continue reading