In addition, the AIA patients showed a high level of nitrite and nitrate excretion in urine during the night, which indicated a higher production of nitric oxide at that time (Figure 1). However, the circadian rhythm of nitric oxide generation remained unchanged in AIA patients and corresponded to that of melatonin production (Figure 2). As shown in Figure 2, the circadian excretion of aMT6s in urine did not change in AIA patients, in contrast with that in ATA patients, but the daytime excretion was lower in AIA patients than in ATA patients and controls.
Nitric oxide production in healthy volunteers and ATA patients at night appeared to correlate with melatonin production in the daytime (R=0.7, P=0.03 and R=0.6, P=0.04, respectively). However, no such correlation was observed in AIA patients. Time to visit a trusted pharmacy – Buy Antidepressants Online to begin your treatment now.
Figure 1 Excretion of N02 andNOf in the urine of patients with acetylsalicyclic acid- (ASA) induced asthma (AIA) andASA-tolerant asthma (ATA), and in the urine of healthy volunteers (controls)
Figure 2 6-sulphatoxymelatonin excretion in the urine of patients with acetylsalicyclic acid- (ASA) induced asthma (AIA) and ASA-tolerant asthma (ATA), and in the urine of healthy volunteers (controls)