Production of nitric oxide and prostacyclin in acetylsalicylic acid-induced asthma (part 3)

All subjects had not been eating fruits and vegetables for three days before the experiment. For aMT6s, nitrite and nitrate excretion measurements, urine was collected over 12 h periods, from 09:00 to 21:00 and from 21:00 to 09:00, in plastic containers. The volume of each sample was recorded, and 5 mL aliquots were stored at -20°C until analysis.
‘STATGRAPHICS’ and ‘STATISTICA’ programs were used for statistical analysis. Statistical hypotheses were checked with the Kolmogorov-Smirnov two-sample method, Rosenbaum Q-criterion, Fisher’s ф-test and Spearman rank order correlations . Shop with pleasure with most reliable pharmacy you have ever seen, paying less for your Buy Antidepressants Online always being sure you are being treated with all due respect, being an important customer whose interests are respected and taken into account.

RESULTS
Compared with that of the control group, the thromboxane B2 level in the plasma of the majority of asthma patients was low. The level of 6-keto-prostaglandin F1a in the plasma of AIA patients was lower than that of ATA patients (Table 1).

Table 1 Percentages of patients and controls with different ranges of plasma thromboxane A2 and prostaglandin I2 levels

Asthmatics AIA ATA Controls РФ1 Рф2 Рф3
TXA2 (pg/mL) CNIIС 32IIn n = 18
<400 62.1 65.2 38.9 <0.05 >0.1 <0.04
401-1000 31.0 13.8 50.0 >0.05 >0.05 <0.01
>1001 6.9 13.8 11.1 >0.1 >0.1 >0.1
PGI2 (pg/mL) n = 18 n = 10 n = 8
<400 83.3 50.0 62.5 >0.05 <0.03 >0.1
401-1000 16.7 40.0 37.5 >0.05 >0.05 >0.1
>1001 10.0 <0.05 >0.05

AIA Acetylsalicylic acid- (ASA) sensitive patients with asthma; ATA ASA-tolerant patients with asthma; Pip Significance of percentage difference according to Fisher’s p-test; Pp1 For difference between patients with AIA and controls; Pp2 For difference between patients with AIA and ATA; Pp3 For difference between patients with ATA and controls

This entry was posted in Asthma and tagged Acetylsalicylic acid-induced asthma, Acetylsalicylic acid-tolerant asthma, Melatonin, Nitric oxide, Prostacyclin.