As postulated for the cervix, vagina, and uterus, relaxin may act directly on both epithelial cells and blood vessels to promote growth and differentiation of the mammary glands and nipples during human pregnancy. Whereas re-laxin’s effects on growth and/or development of the mammary apparatus are dependent upon circulating luteal relax-in in rats and pigs, growth and/or development of the mammary glands in the human may be regulated by autocrine and/or paracrine mechanisms. There is limited evidence that human mammary glands produce small amounts of relaxin. antibiotics levaquin
The physiological significance of relaxin’s binding to the skin of the nipples in the human, rats, and pigs is not known. It may cause a remodeling of the extracellular matrix. Unemori and coworkers found that synthetic human relaxin H2 decreased collagen synthesis by human dermal fibroblasts in vitro and decreased collagen accumulation in vivo in two rodent models of fibrosis. Also, s.c. administration of synthetic human relaxin H2 via an osmotic pump over a three-day period was reported to increase the rate of tissue expansion in male piglets. Relaxin may also contribute to the function of the sebaceous glands. Whereas their function is not clearly understood, the sebaceous glands secrete sebum and, in some species, produce pheromones.