Identification of Specific Relaxin: DISCUSSION(4)

Consider second the possible physiological roles of re-laxin on epithelial cells, blood vessels, stromal cells, and smooth muscle cells in the uterus. As with the cervix and vagina, relaxin may act directly on uterine epithelial cells to contribute to enlargement of the lumen. Relaxin promotes growth of the pig uterus during pregnancy, and Tseng and coworkers reported that porcine relaxin stimulated an increase in cAMP in primary cultures of human endometrial epithelial cells. As with the rat cervix and vagina (unpublished results), relaxin may act directly on blood vessels in the human endometrial stroma to induce their dilation. Relaxin promotes a marked dilation in blood vessels within the mouse endometrial stroma. Relaxin may act on stromal cells within the human endometrium to contribute to their decidualization. my canadian pharmacy corp

When relaxin in combination with progestin was administered to cultured human stromal cells that resembled fibroblasts, there was a dramatic change in the cells to a morphology that resembled decidualized cells. Moreover, the morphological changes were accompanied by an increase in the secretion of prolactin and insulin-like growth factor binding protein-1—two majOTdecidudsecretoryprateisis. Whbereas it seems reasonable to speculate that relaxin acts directly on human myometrial smooth muscle to render the uterus quiescent as it does in rats, pigs, mice, guinea pigs, and other species, that might not be the case. Both highly purified porcine relaxin and synthetic human relaxin H2 demonstrated little or no effect on spontaneous contractility of human myometrial tissues obtained from either pregnant women at cesarean section or nonpregnant women at hysterectomy.

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