There is limited evidence that relaxin may stimulate increased mucin secretion in the rat cervical epithelium. Relaxin may act directly on the blood vessels to induce their dilation as it does in the rat cervix and vagina (unpublished results). Enlargement of blood vessels may provide an adequate blood supply for increased metabolic activity and/or enhanced migration of polymorphonuclear leukocytes into the cervix during late pregnancy in the human. Polymorphonuclear leukocytes have been postulated to release matrix metalloproteinase enzymes that bring about degradation of the extracellular matrix in the human cervix. Relaxin may act directly on stromal cells to promote remodeling of the extracellular matrix. ampicillin antibiotic
Relaxin was reported to promote the secretion of several matrix metalloproteinases and to increase the synthesis of gly-cosaminoglycans in primary cultures of human stromal cells with fibroblast morphology. Endogenous relaxin may act directly on cervical smooth muscle to inhibit its contractility. Norstram and coworkers reported that porcine relaxin inhibited spontaneous contractions of strips of human cervix obtained at term pregnancy. Relaxin’s quiescent effect on contractility of cervical smooth muscle is of unknown physiological significance because it remains to be demonstrated that reduced contractility of cervical smooth muscle contributes to cervical softening.