This study identifies specific relaxin-binding cells in the uterine cervix, vagina, uterus, mammary gland, mammary nipple, and placenta in humans. Additionally, the present study demonstrates for the first time in any species that relaxin binds with specificity to individual cell types within the placenta (amnion, syncytiotrophoblast, blood vessels), and sebaceous glands within the mammary nipples. Cheap Diskus Advair
Whereas it is possible that biotinylated relaxin binds to other proteins, there are at least three reasons to think that the relaxin-binding sites associated with human cells are functional relaxin receptors. First, relaxin-binding was associated with identical cell types in the cervix, vagina, uterus, mammary glands, and mammary nipples of the human as in rats and pigs. Second, in pigs and rats, relaxin elicits a biological response in all tissues in which cells bind relaxin with specificity. Relaxin induces growth and softening of the cervix, growth of the vagina and/or uterus, growth and/or development of the mammary glands, growth of the mammary nipples, expansion of the skin, and reduction in the amplitude of spontaneous contractions of the intestine.