Identification of Specific Relaxin-Binding Cells in the Human Female(1)
In the human, there are two nonallelic genes for relaxin, designated H1 and H2. The corpus luteum is the primary source of circulating relaxin in women, and it produces only H2 relaxin. Plasma relaxin levels are elevated throughout gestation, with maximal levels of approximately 1 ng/ml occurring at about 10 wk of gestation. It is not known if relaxin has physiological roles during pregnancy in humans. Possible physiological roles of circulating relaxin can be extrapolated from findings in rats and pigs, two other species in which the corpus luteum is the source of circulating relaxin during pregnancy.
In rats and pigs, relaxin plays a major role in promoting growth and softening of the cervix, growth of the vagina and/or uterus, and growth and/or development of the mammary glands and nipples. buy asthma inhalers
Small amounts of relaxin H2, and perhaps small amounts of relaxin H1 as well, are produced in human decidua, placenta, and mammary gland. Bryant-Greenwood and coworkers provided evidence that decidual and placental relaxin has local autocrine and/or paracrine roles that contribute to connective tissue remodeling at the maternal-fetal interface during late pregnancy and at parturition.
Tags: Cells, Female, Human, Relaxin