Hormone-Specific Inhibitory Influence: DISCUSSION(16)

The specific structural changes described in this study, i.e., variations in the length of the Man(al-6)Man branch of Asn56 oligosaccharides, appear to have a greater impact on LH activity than on FSH activity. However, larger oligosaccharides are known to exist on FSH from other species; therefore, those hormones should be investigated inorderto determine how much the results obtained with equine gonadotropins can be generalized. asthma inhalers

For many years eCG (PMSG) has been employed as a substitute for FSH, particularly in vivo, where its long circulatory half-life and the synergistic effects resulting from its dual LH/FSH activities stimulate follicular development. The long circulatory half-life makes it a convenient substitute for FSH, as equivalent stimulation with FSH itself usually requires daily or twice-daily injections. Nevertheless, eCG does not act exactly like FSH at the receptor level, and investigators should employ caution when substituting it for FSH.

This entry was posted in Hormone and tagged Equine Gonadotropins, Hormone, Oligosaccharide, Subunit Asn56.