Undifferentiated cytotrophoblast cells of term fetal membranes also express G-CSFR yet do not have invasive properties. On the contrary, trophoblast cells in fetal membranes act as a physiological barrier between the fetus and the mother, and until parturition there is continual exchange of hormones across this barrier, which is necessary for fetal development. In the hemopoietic system, G-CSF is necessary for neutrophilic granulocyte colony formation from bone marrow precursor cells in culture. Subsequent growth in G-CSF-depleted media leads to cell death, while growth in the presence of G-CSF increases cell life span considerably. Placental G-CSFR may mediate similar functions of cell maintenance in trophoblast. buy birth control online
In conclusion, we have demonstrated strict cell type- and developmental stage-specific expression of G-CSFR mRNA and protein during the development of the human placenta. The pattern of expression of placental G-CSFR suggests that G-CSF may have diverse functions in trophoblast invasion and maintenance during placentation, and that the regulated expression of specific G-CSFR proteins may be an important mechanism for facilitating these functions.