Similarly, there is no evidence of a relationship between PLG and biochemical parameters such as plasma lipid profile, hepatitis B virus carrier status and liver function. Chen et al found that glucose intolerance, but not overt diabetes mellitus, is a risk factor for the development of gallbladder polyps. They suggested that gallbladder dys-motility due to hyperglycemia may predispose glucose-intolerant patients to the formation of gallbladder polyps. However, because of the absence of a similar finding in the overtly diabetic patients in their study and in other prevalence studies, the validity of this association is questioned.
As is evident from the above discussion, the lack of any consistent association between PLG and age, sex, body mass index and diabetes mellitus does not resemble the risk factor profile of gallstones. The literature investigating an association between gallbladder polyps and stones is conflicting. Wolpers followed 181 patients with ultra-sonographically diagnosed PLG who were free of gallstones for a mean of 9.5 years. Patients with PLG had no increase in the rate of development of stones compared with a control group comprising people who were free of polyps. Similarly, in their sonographic study of 3608 asymptomatic individuals from Denmark, Jorgensen and Jensen found only three gallbladders containing both stones and polyps. The authors suggested that a negative association between gallstones and PLG may be due to a destructive mechanical effect of mobile stones on gallbladder polyps or to difficulties in identifying PLG sonographically in the presence of gallstones. Others, however, have found a positive association between gallbladder polyps and stones. Very cheap drugs at your disposal – buy birth control online to get best deals at best pharmacy.
Gallbladder polyps also occur in patients with congenital gastrointestinal syndromes associated with polyp formation in the intestines, including the Peutz-Jeghers syndrome and Gardner’s syndrome. The frequency of gallbladder polyps may also be increased in patients with HIV infection. In a study of 83 HIV-positive patients who underwent endoscopic retrograde cholangiopancreatography for the investigation of cholestatic liver enzymes or abdominal pain, an admittedly selected population, 15 patients (18.1%) were found to have intraluminal polyps.