Many studies have attempted to determine individual risk factors that predispose patients to the formation of PLG. The impact of demographic factors such as patient age and sex have been variable. Although most reports have documented the highest prevalence of gallbladder polyps in the third to fifth decades of life, consistent associations with patient age have not been reported. For example, using multivariate analysis, Chen et al failed to show an effect of age on the development of PLG in Chinese subjects. Other investigators have found similar findings. Conversely, Segawa and colleagues reported a significant age-dependent prevalence of PLG in Japanese men and in women under the age of 70 years, with the highest prevalence occurring in 40- to 50-year-old men. The impact of sex on the formation of PLG also has been discordant across studies. Some reports find that gallbladder polyps are more common in males, whereas others note an increased frequency in females or no difference between the sexes. Overall, PLG seem to predominate in males, unlike gallstone disease. In the largest screening study to date involving 194,767 Japanese participants, Okamoto et al reported PLG in 6.9% of males and 4.5% of females. Best quality drugs are waiting – diabetes drugs to spend less time and money.
Significant effects of other demographic variables on the prevalence of PLG have not been identified. Although obesity has occasionally been associated with the development of PLG, other demographic factors such as physical activity, parity, use of exogenous female hormones and alcohol consumption appear to be less important. Jorgensen and Jensen reported that smoking has a protective effect in men only, but other investigators have not reproduced their findings.