Over the past 20 years, the increased availability and improved image quality of abdominal ultrasonography have led to a dramatic increase in the detection of abnormalities of the biliary tree, including polypoid lesions of the gallbladder (PLG). Defined sonographically as immobile echoes protruding from the gallbladder wall into the lumen, PLG comprise several histopathological entities. In 1970, Christensen and Ishak proposed a simple classification of benign PLG that allowed separation of neoplastic from non-neoplastic conditions. Based on an analysis of 180 cases of benign gallbladder polyps, the authors classified benign PLG into pseudotumours, including, most commonly, cholesterol polyps, adenomyomatosis and inflammatory polyps, and true tumours, including adenomas, leiomyomas and lipomas. Distinguishing these benign PLG from malignant and potentially malignant lesions is a major diagnostic dilemma with important clinical implications. The present review highlights the epidemiology, modes of diagnosis and natural history of gallbladder polyps in the adult population. The differentiation of benign from malignant PLG is discussed, and evidence-based recommendations for the management of these lesions are provided. Find best deals online – asthma inhalers can be available every time you visit.