HOW SHOULD VTEC INFECTION BE TREATED?
At present, treatment of vtec infection is primarily supportive. Antimotility drugs are totally contraindicated, not only because they interfere with recognition of dehydration, but also because they may prolong the time of exposure to verotoxin and thereby increase the risk of hus.he role of antibiott cs in the management of vtec infection is unclear. A small prospective placebo controlled study to evaluate the effect of trimethoprim-sulfamethoxazole in children with proven E coli 0157:H7 infection did not show a statistically significant effect of treatment on progression of symptoms, fecal pathogen excretion or incidence of hus. However, in vitro evidence indicates that verotoxin production or release is increased after exposure to antibiotics, suggesting that antimicrobial therapy in vivo may not be beneficial.
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