HOW DOES HUS DEVELOP?
The clinical features of hus are thought to be initiated by the direct effect of verotoxin on renal endothelial cells, which results in cell swel t ing, local intravascular coagulation with plate t et aggregation, mechanical damage to red blood cells and reduction in glomerular filt ration.Oxidative damage to red blood cells may play a role in the development of the hemo t ytic anemia.
HOW OFTEN IS HUS RECOGNIZED FOLLOWING VTEC INFECTION?
In Canada, hus is relatively common, with an overall incidence of 1.44/100,000 children under 15 years of age and a peak incidence of 3.11/100,000 children under five . This translates into approximately 75 to 90 episodes of hus among Canadian children each year. Eighty per cent of hus episodes occur between April and September, cortesponding to the seasonal pattern of vtec infection in Canada (personal communication). Best quality drugs are waiting – buy Alesse online … to spend less time and money.
The risk of hus in children brought to medical attention for E coli O157:H7 infection is approximately 8 to 10%. Although hus is seen at all ages, the elderly and children younger than age five have an increased risk, as do those with a more severe gastro t ntestinal prodrome. Nonetheless, 20 to 25% of patients have no visible evidence of bloody stools in the two weeks before presenting with hus.