Escherichia coli O157:H7, other verotoxin-producing E coli and the hemolytic uremic syndrome in childhood: part 1


BACKGROUND AND NOMENCLATURE vtec are so named because of their ability to produce one or more exotoxins (VT-1, VT-2, VT-2 variant) that have cyto-pathic effects on vero cells (African green monkey kidney cells). vtec affect other cell lines as well. VT-1 is also known as shiga-like toxin because of its structural and functional similarity to the toxin produced by Shigella dysenteriae 1.
In contrast to some of the other causes of gastroenteritis, vtec cause disease not by local invasion of the gut mucosa but by the direct action of verotoxin on certain cells. Verotox-ins bind to a specific glycolipid receptor, Gb3, found on endo-thelial cells of blood vessels, smooth muscle cells, renal endothelial cells and red blood cells. Once bound, verotoxins inhibit intracellular protein synthesis, thereby causing cell death. Because the structure of Gb3 is identical to that of the Pk antigen in the P blood group system, it is not surprising that P blood group status appears to influence the risk of developing hus after vtec infection. vtec that produce VT-2 alone or in combination with VT-1 are more commonly associated with hus than are organisms that produce VT-1 alone. Shop with best online pharmacy and find >>> vardenafil online pharmacy getting the most out of it.

This entry was posted in Escherichia coli O157:H7 and tagged Escherichia coli O157:H7, GASTROENTERITIS, O157:H7 INFECTION.