Effects of indapamide versus hydrochlorothiazide: ROUTINE SAFETY LABORATORY TESTS


Routine laboratory tests were carried out in the hospital laboratory. The laboratory tests performed at the beginning (visit 1) and end of the study (visit 9) included the following determinations: platelet and blood cells counts, serum electrolytes (sodium, potassium and chloride), fasting blood glucose, serum uric acid, serum creatinine and aspartate aminotransferase; urine was assessed by dipstick.


Complaints and adverse drug effects were recorded as spontaneous reports and detailed (duration, severity, possible etiology) at each visit. buy ortho tri-cyclen


Two-way ANOVA with repeated measures was used to compare HCTZ with indapamide across time (after washout at visit 3 versus end of study at visit 9). A significant drug-time interaction was taken to indicate differences in drug effects over time. One-way ANOVA was used for comparisons between groups with respect to variables not affected by treatment, such as age and sex, or comparisons not affected by time, such as baseline comparisons. ANCOVA using baseline systolic pressure as the covariate, and a t test for change score for systolic pressure, were used to determine whether the apparent difference in SBP effects was due to differences in baseline pressure.

This entry was posted in Hydrochlorothiazide and tagged Diuretics, Hydrochlorothiazide, Indapamide, Lipids, Metabolic effects.