Effects of indapamide versus hydrochlorothiazide: INCLUSION CRITERIA


Patients eligible for recruitment were men or women aged 18 to 75 years with mild to moderate primary hypertension (sitting systolic pressure 160 mmHg or diastolic pressure 95 to 105 mmHg); untreated or formerly treated with a single first-line antihypertensive agent with no history of recent severe cardiac or cerebrovascular complications; and a fasting serum TC level of 4.7 to 7 mmol/L.


Excluded were women of child-bearing potential; patients who had experienced a myocardial infarction within the past six months or with angina pectoris; patients with clinical evidence of congestive heart failure, a stroke within the past three months, clinically significant aortic stenosis, significant arrhythmias, or conduction disturbances requiring treatment with antiarrhythmic medication, a resting heart rate greater than 100 beats per minute, diabetes mellitus, hypo- or hyperthyroidism, clinically significant hepatic, systemic, hematological, central nervous system or metabolic disease, including gout; patients with secondary, accelerated or malignant hypertension, systolic blood pressure less than 110 mmHg, laboratory tests outside the reference range, except lipid levels; patients taking digoxin or cimetidine therapy; patients with a history of chronic or intermittent diarrhea or use of laxatives on a chronic basis; patients with a history of noncompliance, alcoholism or drug abuse; patients who weighed more than 20% above their ideal body weight, as defined by Metropolitan Life Tables; and patients with a history of drug-related lipid abnormalities or hypersensitivity to sulphonamides. Patients taking drug treatments for hyper-lipidemia and those who intended to change their diet during the course of the study were also excluded.

This entry was posted in Hydrochlorothiazide and tagged Diuretics, Hydrochlorothiazide, Indapamide, Lipids, Metabolic effects.