Effects of indapamide versus hydrochlorothiazide: DISCUSSION(1)



Because there was no difference between treatments for the main effect, the post hoc power of the study was calculated to show an effect significant at the 0.05 level if a true difference existed, using standard methods . The power of the study to detect a difference if a difference really exists was 97.3%; the value of beta, a type II error, ie, the probability of failing to reject the null hypothesis (above) when it is false, was 2.8%. buy flovent inhaler


The issue of effects of antihypertensive drugs on lipids is potentially important because the objective of treating hypertension is to reduce the vascular complications. Reduction of cholesterol levels by 9% to 20% appears to reduce coronary risk by approximately 2% for every 1% reduction in the level of cholesterol. It thus appears likely that if diuretics adversely affect lipid profiles, that effect might substantially reduce the benefit of treating hypertension. Indeed, two groups have estimated that the adverse effects of beta-blockers and diuretics on lipids are enough to offset completely the benefit of treating mild hypertension. It should be noted that such analyses bear indirectly on the question of risk reduction, that those papers date from a time when diuretic doses were commonly higher than those used now and that the main beta-blockers in use then were nonselective.

This entry was posted in Hydrochlorothiazide and tagged Diuretics, Hydrochlorothiazide, Indapamide, Lipids, Metabolic effects.