Effects of hypoxia on myoglobin and antioxidant enzymes in rat myocardium (part 8)

rat myocardium (part 8)

DISCUSSION
Myoglobin acts as an intracellular oxygen reservoir and an oxygen shuttle in the myocardium of mammals . Myoglobin is needed to maintain oxygen uptake because of the low oxygen tension under conditions of hypoxia . Our previous studies observed that myoglobin expression is accelerated with the prolongation of hypoxic exposure (48 h) and that restoration of myoglobin content occurs after reoxygenation (24 h) in cultured cardiac myocytes . This suggests that the augmentation of myoglobin under hypoxia is compensatory. In the present study, we observed that the myoglobin concentration of both the left and right myocardium increased significantly after continuous hypoxia (3500 m for four weeks) and right ventricular myocardium weight increased. If you want for your health problem to stop bothering you once and for all, you need an efficient medicine, the kind that you can easily purchase at the best canadian neighbor pharmacy viagra, always offering very affordable prices and fast delivery.

This suggests that more myoglobin is needed to maintain the oxygen supply under hypoxia. We report the first measurement of myoglobin content under intermittent hypoxia. There is no increase in myoglobin concentration or ventricular weight under conditions of intermittent hypoxia. Under conditions of intermittent hypoxia, the rat responded with stable long term adaptation to hypoxia, which was caused by regular reduction of the oxygen content in the air. The apparently reduced need for more myoglobin is probably due to this adaptation to hypoxia.

 

This entry was posted in Myocardium and tagged Antioxidant enzymes, Intermittent hypoxia, Myoglobin.