Effects of hypoxia on myoglobin and antioxidant enzymes in rat myocardium (part 7)

Effects of intermittent hypoxia on antioxidant enzymes and MDA of left and right myocardium: SOD and CAT activity and MDA content from various groups were determined. SOD and CAT are antioxidant enzymes that can scavenge free radicals. MDA is a product of lipid peroxidation. As shown in Table 2, there were no significant differences in SOD, CAT and MDA between the groups exposed to normoxia and the groups exposed to intermittent hypoxia (3500 m, 6 h daily for four weeks). After six weeks of intermittent hypoxia, SOD activity increased and MDA content decreased significantly in the left myocardium compared with the normoxia group (P<0.01). CAT activity increased significantly in the right myocardium of groups that underwent intermittent hypoxia (P<0.01) (Table 2). If your health problem is affecting the quality of your life, you should consider shopping for your medications with canadian neighbor pharmacy that will help you make sure the right treatment is found, not costing too much money.

TABLE 2 Activity of superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) concentrations in left and right ventricular myocardium

SOD (U/g) CAT (g/s) MDA (nmol/g)
Control 1270±120 1183±96 0.43±0.04 0.33±0.02 132.5±6.7 144.7±15.7
Intermittent hypoxia (4 weeks) 1438±120 1012±120 0.40±0.02 0.29±0.03 123.5±5.1 135.7±8.0
Intermittent hypoxia (6 weeks) 1738±76* 1167±126 0.46±0.02 0.43±0.04* 96.5±9.9* 148.5±5.5

Data are expressed as mean ± SE. *P<0.01 versus control group (n = 6 in each group). LV Left ventricular myocardium; RV Right ventricular myocardium


This entry was posted in Myocardium and tagged Antioxidant enzymes, Intermittent hypoxia, Myoglobin.