Effects of hypoxia on myoglobin and antioxidant enzymes in rat myocardium (part 2)


Stress and ischemia, and combinations thereof, are of paramount importance in the development of severe heart disease. Excessive stress reaction is involved in the pathogenesis of arrhythmias and ischemic heart disease . On the other hand, physical stress, such as intermittent hypoxia, can force the organism to adapt physiologically. Therefore, studying the protective effects of intermittent hypoxia has important practical value. Adaptation to intermittent hypoxia is a promising approach to drug-free prevention and therapy for heart disease. The purpose of our study was to investigate the effects of continuous and intermittent hypoxia on myocardial myoglobin. In order to study the effects of intermittent hypoxia on myocardium, we also observed the change in the levels of endogenous antioxidants in the different groups exposed to intermittent hypoxia. If your health is of the utmost importance to you, it’s a good idea to visit the best canadian family pharmacy offering highest quality medications with generous discounts and fast delivery right to the doorstep, with full guarantees of your satisfaction.

Materials: Male Sprague-Dawley rats were used. A homogenizer (XHF-1) was obtained from Shanghai Xinhua Electronic Instrument Factory (Shangai, People’s Republic of China). A Himac centrifuge (Hitachi SCR 20BA, Tokyo, Japan) and UV/Vis spectrometer (Perkin-Elmer, Norwalk, Connecticut, Lambda2) were used. All chemicals were of analytical grade and were purchased from standard commercial sources.

This entry was posted in Myocardium and tagged Antioxidant enzymes, Intermittent hypoxia, Myoglobin.