Effects of hypoxia on myoglobin and antioxidant enzymes in rat myocardium (part 1)

rat myocardium (part 1)

Myocardium is sensitive to ischemia or hypoxia, partly because of its high concentration of oxidative enzymes and high demand for oxygen. Under normal conditions, as much as 60% to 80% of coronary blood oxygen is taken up by the myocardium, which contributes to its high myoglobin concentration. Myoglobin is an intracellular heme-protein found in the muscles of mammals, especially in cardiac tissue. It stores and shuttles oxygen in myocytes. Therefore, the concentration of myocardial myoglobin is an important physiological and biochemical indicator, and influences myocardial performance . Early studies by Millikan demonstrated that the concentration of myoglobin increases in skeletal muscles undergoing vigorous and continuous activity. The concentration of myoglobin is also known to increase during high altitude hypoxia in both humans and animals .Although an increasing number of studies are paying attention to myoglobin functions, few studies have examined the effects of intermittent hypoxia on myocardial myoglobin. In contrast to continuous hypoxia, intermittent hypoxia is the exposure of animals to repetitive, relatively mild, brief hypoxia, to which the animal successfully adapts, acquiring a remarkably high resistance to severe, previously lethal hypoxia . For intermittent hypoxia, the procedure usually consists of 30 to 40 seances, during which animals undergo not only hypoxia, but also 30 to 40 instances of slow reoxygenation according to Meerson’s description . Physiological responses to intermittent hypoxia (or preconditioning) and their mechanisms have been the subject of many investigations in recent years . Take care of your health right now: it’s now so easy to stop the disease from affecting your life. This helpful *pharmacy is always available no matter which medicine you need and how much of it, for your health to be restored soon.

This entry was posted in Myocardium and tagged Antioxidant enzymes, Intermittent hypoxia, Myoglobin.