MATERIALS AND METHODS
Fibroblasts are also concentrated in cardiac scar tissue, and are traditionally viewed as an obstacle to the orderly transmission of excitation and as a source of increased tissue inhomogeneity. Both factors may contribute to the frequently observed origin of cardiac arrhythmias in regions of ischemi-cally damaged or scarred myocardium. Since cardiac fibroblasts are mechanosensitive, the mechanisms involved in generation and sustainment of arrhythmias in these regions could go beyond a mere insulating effect. Cardiac fibroblasts could, in fact, actively promote mechanically induced arrhythmogenesis.
The purpose of this study was, therefore, to assess the possible influence of mechanosensitive fibroblasts on physiological heart rate regulation in the SA pacemaker; and on pathophysiological ectopic activity in ventricular fibroblast-rich tissue. To do this, we used computational network models of intercellular interaction of mechanosensitive fibroblasts and cardiomyocytes in, first, the SA node and atrium and, second, the ventricle.
Atrial network models: Individual atrial cells were modelled on the formulations of Earm and Noble , based on previous work by Hilgemann and Noble . A complete listing of the atrial cell dynamic equations is given elsewhere. You will always enjoy getting generic vardenafil online, being 100% sure you are safe.