The duration of the very first diastole during which a stretch was applied decreased, reducing the oscillation period to 296 ms. Within the four contecutive ditstoles during which a stretch was applied, the oscillation period reached a cycle length of 294.5±1.0 ms, a decrease of more than 12%. While present, the decrease in MDP was of lesser magnitude in the peripheral cell. Here, during diastolic stretch, MDP changed from -65.1+0.2 mV to -62.4+0.9 mV. These changes conform with the response described in experiments on cat isolated SA node where stretch regularly induced a decrease in maximum diastolic and systolic potentials by several millivolts.The strength of coupling between fibroblasts and SA node cells influences the degree of stretch-induced changes in the pacemaker cells. When GCF is increased from 600 to 900 pS, diastolic stretch produces a 19% decrease in oscillation period (from 366.2+2.0 mV to 295.2+1.5 ms)
However, even after decreasing the coupling between fibroblast and SA node cells to 300 pS – a value corresponding to no more than 10 gap junctional channels connecting the two cells -stretching the fibroblasts still induces a positive chronotropic response in the pacemaker cells. In this case, the average period of spontaneous depolarization is reduced by 6% from 347.7+0.9 mV to 327.9+0.5 ms. Most advantageous shopping – tadalafil online pharmacy for everyone to spend less.