In 24 h Holter ECG monitoring after one week and six months of antiarrhythmic therapy a significant difference was observed in minimal heart rate. The lowest heart rate was observed in the sotalol group (Tables 3,4).
Adverse side effects: Several cardiovascular and noncardio-vascular side effects were associated with therapy (Table 5). There were no significant differences among studied groups.
TABLE 3 24 h Holter electrocardiogarphic monitoring after one week of therapy with disopyramide, propafenone or sotalol therapy
|Sinus rhythm (beats/min)||Disopyramide(n=19)||P||Propafenone (n = 18)||P||Sotalol(n=19)|
|AF/SVT <30 s||5 (26%)||NS||5 (28%)||NS||4 (18%)|
|AF/SVT Atrial fibrillation||or supraventricular tachycardia less than 30 s;||NS Not significant|
TABLE 4 24 h Holter electrocardiographic monitoring after six months of therapy with disopyramide, propafenone or sotalol
|(beats/min)||(n = 15)||P||(n = 13)||P||(n = 14)|
|AF/SVT <30 s||5 (30%)||NS||6 (43%)||NS||5 (31%)|
AF/SVT Atrial fibrillation or supraventricular tachycardia less than 30 s; NS Not significant
TABLE 5 Occurrence of adverse effects associated with disopyramide, propafenone and sotalol therapy
|Bradycardia||1 (4%)||0||2 (10%)|
|Congestive heart failure||1 (4%)||0||1 (4%)|
|Gastrointestinal||1 (4%)||2 (10%)||0|
|Central nervous system||1 (4%)||1 (4%)||1 (4%)|
|Stopped medication due to side effects||2 (8%)||1 (4%)||1 (4%)|
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