Comparison of disopyramide, propafenone and sotalol after direct current cardioversion of chronic atrial fibrillation (part 6)

In 24 h Holter ECG monitoring after one week and six months of antiarrhythmic therapy a significant difference was observed in minimal heart rate. The lowest heart rate was observed in the sotalol group (Tables 3,4).
Adverse side effects: Several cardiovascular and noncardio-vascular side effects were associated with therapy (Table 5). There were no significant differences among studied groups.

TABLE 3 24 h Holter electrocardiogarphic monitoring after one week of therapy with disopyramide, propafenone or sotalol therapy

Sinus rhythm (beats/min) Disopyramide(n=19) P Propafenone (n = 18) P Sotalol(n=19)
Maximal 114±18.9 NS 103±13.3 NS 102±18.2
Minimal 46±7.8 <0.05 52±6.2 <0.001 40±6.0
Mean 69±11.6 NS 72±11.5 NS 66±8.5
AF/SVT <30 s 5 (26%) NS 5 (28%) NS 4 (18%)
AF/SVT Atrial fibrillation or supraventricular tachycardia less than 30 s; NS Not significant

TABLE 4 24 h Holter electrocardiographic monitoring after six months of therapy with disopyramide, propafenone or sotalol

Sinus rhythm Disopyramide Propafenone Sotalol
(beats/min) (n = 15) P (n = 13) P (n = 14)
Maximal 108±8.4 NS 112±8.5 NS 112±14.1
Minimal 45±5.7 <0.05 52±5.3 <0.01 41±5.8
Mean 65±8.3 NS 70±4.2 NS 64±3.9
AF/SVT <30 s 5 (30%) NS 6 (43%) NS 5 (31%)

AF/SVT Atrial fibrillation or supraventricular tachycardia less than 30 s; NS Not significant

 

TABLE 5 Occurrence of adverse effects associated with disopyramide, propafenone and sotalol therapy

Adverse effect Disopyramide Propafenone Sotalol
Bradycardia 1 (4%) 0 2 (10%)
Congestive heart failure 1 (4%) 0 1 (4%)
Proarrhythmia 0 1 (4%) 0
Gastrointestinal 1 (4%) 2 (10%) 0
Central nervous system 1 (4%) 1 (4%) 1 (4%)
Stopped medication due to side effects 2 (8%) 1 (4%) 1 (4%)

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This entry was posted in Cardiology and tagged Antiarrhythmic therapy, Cardioversion, Chronic atrial fibrillation.