Comparison of disopyramide, propafenone and sotalol after direct current cardioversion of chronic atrial fibrillation (part 5)

atrial fibrillation (part 5)In the primary efficacy assessment, 15 of 24 patients (63%) treated with disopyramide, 13 of 22 (59%) with propafenone and 14 of 23 (61%) with sotalol were in sinus rhythm and on antiarrhythmic treatment at the six-month follow-up (not significant). After 12 months of follow-up, 11 of 24 patients (46%) on disopyramide, 10 of 22 (45%) on propafenone and 12 of 23 patients (52%) on sotalol therapy were still in sinus rhythm. There was no significant difference in maintaining sinus rhythm among studied groups.
In the primary efficacy assessment, AF recurred in 11 of 24 patients (46%) with disopyramide, 11 of 22 (50%) with propafenone and 10 of 23 (43%) with sotalol (not significant). Table 2 shows the primary efficacy of three drugs in maintaining sinus rhythm and recurrence of AF at 12 mon. Looking for a great online pharmacy you could trust and where you could find viagra professional canadian pharmacy buy now at best prices? You have one pharmacy like that already and can finally enjoy the best quality of service ever experienced.

TABLE 2 Clinical characteristics of study groups treated for maintenance of sinus rhythm following direct current cardiovsersion

Disopyramide(n=24) Propafenone(n=22) Sotalol(n-23)
Age (years) 61.9±9.3 64.3±6.3 63.7±11.1
Sex (male:female) 13:11 10:12 11:12
Mean duration of AF (months) .6cd±

.9

4.

5.1±9.1 3.9±5.8
Occurrence of underlying heart disease*
Hypertension 9 (38%) 10 (45%) 8 (35%)
Ischemic heart disease 14 (58%) 12 (55%) 13 (57%)
After myocardial infarction 2 (8%) 1 (5%) 2 (9%)
Congestive heart failure 7 (29%) 8 (36%) 8 (35%)
Cardiomyopathy 2 (8%) 2 (9%) 2 (9%)
Lone AF 4 (17%) 3 (14%) 3 (13%)
Echocardiographic findings
Left atrial size: long axis view (mm) 44.1±5.3 44.9±4.7 44.5±6.4
Left ventricular end-diastolic diameter (mm) 51.1±5.4 51.5±4.3 52.8±5.4

*More than one disease entity per patient. There were no significant differences among study groups. AF Atrial fibrillation

This entry was posted in Cardiology and tagged Antiarrhythmic therapy, Cardioversion, Chronic atrial fibrillation.