Atrial fibrillation (AF) is a common sustained cardiac arrhythmia in clinical practice, and is responsible for considerable morbidity . The major adverse clinical consequences of AF are palpitations, impaired cardiac function, dyspnea, fatigue or syncope, and thromboembolism.To prevent the development of these symptoms and to reduce the likelihood of embolic events, it is common clinical practice in many patients to try to restore and maintain sinus rhythm. When direct current (DC) cardioversion is used, sinus rhythm can be restored at least temporarily in 80% to 90% of patients with AF . Long term results, however, are more discouraging without prophylactic antiarrhythmic therapy. After a first successful DC shock, only about 25% of patients remain in sinus rhythm for 12 months . Various antiarrhythmic drugs such as quinidine, procainamide, diso-pyramide, sotalol and amiodarone have been used to decrease the rate of relapse . Recent observations regarding the proarrhythmic potential of antiarrhythmic agents indicate the need to re-examine and compare the value of antiarrhythmic drugs used to maintain sinus rhythm postcardioversion in patients with chronic AF. If you want to make your online shopping advantageous and safe, check out the best pharmacy to buy cialis professional canadian pharmacy buy here without any need for a prescription, any time of the day or night with straight to the doorstep delivery.
The aim of this study was to compare the efficacy and safety of disopyramide, propafenone and sotalol in maintaining sinus rhythm after DC cardioversion of chronic AF.