Category Archives: Septic Shock

Glucose-Insulin and Potassium Infusions in Septic Shock: Conclusion

Insulin decreases circulating levels of IL-1p, IL-6, migration inhibitory factor, TNF-a, and increases levels of IL- 4 and IL-10 in thermally injured rats. In lipopo-lysaccharide-treated animals, insulin suppresses TNF-a in a dose-dependant manner. Furthermore, insulin reduces proinflammatory and increases antiinflammatory … Continue reading

Glucose-Insulin and Potassium Infusions in Septic Shock: Discussion

We have described two cases of neutropenic septic shock in which the administration of a high-dose GIK infusion was temporally associated with an improvement in hemodynamic profile, permitting cessation of inotropic support. Septic shock and the systemic inflammatory response is … Continue reading

Glucose-Insulin and Potassium Infusions in Septic Shock: Definition

An ECG showed no acute changes, and results of CT of the head were normal. A diagnosis of neutropenic septic shock secondary to hospital-acquired pneumonia was made. Broad-spectrum antimicrobials (teicoplanin, ceftazidime, amphotericin, and foscarnet) were immediately commenced, and the patient … Continue reading

Glucose-Insulin and Potassium Infusions in Septic Shock: Case

Oliguria and acidemia ensued (pH 7.25; Pco2, 52 mm Hg; Po2, 74 mm Hg; base excess, -5; bicarbonate, 20 mmol/L) necessitating continuous veno-venous hemofiltration. Over the following 8 h, increasing infusions of epinephrine (rising to a maximum of 56 |xg/min) … Continue reading

Glucose-Insulin and Potassium Infusions in Septic Shock

Septic shock carries a high attendant risk of death to which impaired myocardial contractility may contribute. Recent interest in the use of glucose-insulin and potassium (GIK) infusions as therapy in ischemic myocardial depression has extended to septic myocardial depression. Few … Continue reading