Category Archives: Relaxin

Identification of Specific Relaxin: DISCUSSION(7)

In this study, we also found that there were no apparent differences in the distribution and intensity of labeling in cervices obtained from nonpregnant women after hysterectomy and women after cesarean section at term (data not shown). Thus available data … Continue reading

Identification of Specific Relaxin: DISCUSSION(6)

The identification of relaxin-binding on the amnion epithelial cells, syncytiotrophoblast, blood vessels and stromal cells within the term placenta is consistent with Bryant-Greenwood and coworkers’ hypothesis that decidual and/ or placental relaxin acts locally via autocrine and/or paracrine mechanisms. The … Continue reading

Identification of Specific Relaxin: DISCUSSION(5)

As postulated for the cervix, vagina, and uterus, relaxin may act directly on both epithelial cells and blood vessels to promote growth and differentiation of the mammary glands and nipples during human pregnancy. Whereas re-laxin’s effects on growth and/or development … Continue reading

Identification of Specific Relaxin: DISCUSSION(4)

Consider second the possible physiological roles of re-laxin on epithelial cells, blood vessels, stromal cells, and smooth muscle cells in the uterus. As with the cervix and vagina, relaxin may act directly on uterine epithelial cells to contribute to enlargement … Continue reading

Identification of Specific Relaxin: DISCUSSION(3)

There is limited evidence that relaxin may stimulate increased mucin secretion in the rat cervical epithelium. Relaxin may act directly on the blood vessels to induce their dilation as it does in the rat cervix and vagina (unpublished results). Enlargement … Continue reading

Identification of Specific Relaxin: DISCUSSION(2)

Third, in this study, specific relaxin binding was found in human skin and placenta, and synthetic human relaxin was recently reported to demonstrate a biological response in human skin and placental tissue. Establishment of receptor binding requires structural characterization of … Continue reading

Identification of Specific Relaxin: DISCUSSION(1)

This study identifies specific relaxin-binding cells in the uterine cervix, vagina, uterus, mammary gland, mammary nipple, and placenta in humans. Additionally, the present study demonstrates for the first time in any species that relaxin binds with specificity to individual cell … Continue reading

Identification of Specific Relaxin: RESULTS(3)

Immunohistochemistry results from sections of the mammary nipples are shown in Figure 5. Prominent labeling with the biotinylated relaxin was observed in epithelial cells of lactiferous duct, smooth muscle cells, and skin (Fig. 5A). Prominent labeling was also observed in sebaceous … Continue reading

Identification of Specific Relaxin: RESULTS(2)

Immunohistochemistry results from sections of the uterus are shown in Figure 3. Prominent labeling of both luminal and glandular epithelial cells and myometrial smooth muscle cells was observed in sections incubated with bio-tinylated relaxin (Fig. 3, A and B). Labeling … Continue reading

Identification of Specific Relaxin: RESULTS(1)

Samples of each tissue collected showed qualitatively similar results. Immunohistochemistry results from sections of cervix collected at hysterectomy are shown in Figure 1. Prominent labeling of luminal epithelial cells, smooth muscle cells, and cells associated with blood vessels was observed in … Continue reading

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