Category Archives: Multinodular Disease

Multinodular Disease: Conclusion

LIP is most often seen in patients with underlying immunologic abnormalities, especially Sjogren syndrome and AIDS, and is characterized histologically by diffuse hyperplasia of bronchus-associated lymphatic tissue, resulting in a diffuse, polyclonal lymphoid cell infiltrate surrounding the airways and expanding … Continue reading

Multinodular Disease: Discussion

Those cases in which centrilobular nodules are present in patients in the absence of tree-in-bud opacities constitute the last part of this CT scan algorithm (Table 1). Included in this category are a variety of diseases or “mixed” entities that … Continue reading

Multinodular Disease: Results

While classically described in patients with an endobronchial spread of tuberculosis, in fact, tree-in-bud opacities can be identified in virtually any type of infectious bronchiolitis. This includes Mycobacterium tuberculosis, Mycobacterium avium-intra-cellulare, bacterial, viral, and fungal infections, and allergic bronchopulmonary mycosis. … Continue reading

Multinodular Disease: Steps

Group 2: In distinction with the patterns described in patients in group 1, group 2 includes those patients in whom no or very few nodules are perifis-sural or subpleural in distribution. Anatomically, these nodules are grouped together as being centri-lobular … Continue reading

Multinodular Disease: Treatment

A basilar predominance is typically noted due to preferential blood flow to the lung bases. Individual nodules may have “feeding vessels” consistent with their hematogenous origin. On HRCT scans, a connection between nodules and the adjacent pulmonary vessels (ie, the … Continue reading

Multinodular Disease: Study

The most important differential diagnoses for this pattern of disease are silicosis and coal worker pneumoconiosis. In both of these occupational diseases, perilymphatic nodules are the primary abnormality, typically involving the mid and upper lung fields. While these entities may … Continue reading

Multinodular Disease: Definition

Group 1: Those cases in which a striking proportion of nodules demonstrate pleural or perifissural involvement characterize nodules as predominantly perilymphatic or lymphohematogenous in origin, constituting a separate arm of the algorithm (Table 1). The explanation for this pattern lies … Continue reading

Multinodular Disease: Morphologic Characterization

Diseases that are primarily hematogenous in origin, such as miliary infections or hematogenous metasta-ses, give rise to nodules that are randomly distributed throughout the secondary lobule, with the greatest profusion in the lung bases (Fig 3). These patterns are clearly … Continue reading

Multinodular Disease

For the purposes of this report, multinodular disease will be defined in a patient in which there are too many nodules to easily count on routine CT scan studies, with most of these nodules measuring < 1 cm in diameter. … Continue reading