Category Archives: Growth Factor

Insulin-Like Growth Factor-2 Regulation of Conceptus Composition: DISCUSSION(8)

IGF-2 and the Control of Cell Population Size In Vivo The main effect of Igf2 ko on the fetus and yolk sac results from low IGF-2 production by the derivatives of the ICM, with both parts suffering more than a … Continue reading

Insulin-Like Growth Factor-2 Regulation of Conceptus Composition: DISCUSSION(7)

It is not known if one or many exchange tissues are involved in regulating the extracellular fluid volume in the mouse conceptus. It is unlikely that the number of cells is a major determinant. There is only a 15% decrease … Continue reading

Insulin-Like Growth Factor-2 Regulation of Conceptus Composition: DISCUSSION(6)

Later, the degeneration of Reichert’s membrane leaves the visceral yolk sac exposed as an extensive bounding barrier and fluid exchange may occur here, as well as at the placenta. The fluid content of the normal exocelomic plus amniotic cavities is … Continue reading

Insulin-Like Growth Factor-2 Regulation of Conceptus Composition: DISCUSSION(5)

Deficiency of IGF-2 in the trophoblast decreased the mean fetal placenta weight by 21%, and deficiency in the ICM derivatives decreased it by 14% (Table 4). There was no significant change in the DNA content in either case (Table 5), … Continue reading

Insulin-Like Growth Factor-2 Regulation of Conceptus Composition: DISCUSSION(4)

Placental wet weight is increased by IGF-2 excess, as seen in Igf2r ko mice, and decreased by IGF-2 deficiency, as observed in Igf2 ko mice and this study). The mouse placenta is an anatomical unit in which maternal decidual tissue … Continue reading

Insulin-Like Growth Factor-2 Regulation of Conceptus Composition: DISCUSSION(3)

In the present small experimental series of litters, the following additional variables did not have significant effects: number of viable embryos in the litter, position in the uterus, or the size or Igf2 status of nearest neighbors. In each recombination … Continue reading

Insulin-Like Growth Factor-2 Regulation of Conceptus Composition: DISCUSSION(2)

These early postimplantation interactions show that the growth of one part is dependent on the other. In addition, the growth of the whole conceptus is clearly subject to size regulation, because combined whole morulae develop into pups of normal size. buy … Continue reading

Insulin-Like Growth Factor-2 Regulation of Conceptus Composition: DISCUSSION(1)

IGF-2 and Growth of the Conceptus IGF-2 production by the conceptus begins to alter its size from E10.5. Substantial quantities of Igf2 mRNA can first be detected by autoradiography at E5.5 in trophectoderm derivatives, at E6.5-7.0 in the extra-embryonic endoderm … Continue reading

Insulin-Like Growth Factor-2 Regulation of Conceptus Composition: RESULTS(2)

Recombination Experiments The development of the recombined blastocysts to viable E16.5 conceptuses was recorded (Table 2). There was no evidence that an Igf2 ko component in either the trophec-toderm or the ICM derivatives influenced the success of development after the … Continue reading

Insulin-Like Growth Factor-2 Regulation of Conceptus Composition: RESULTS(1)

In all experiments, the Igf2 null allele was transmitted by a heterozygous father, giving the genotypes Igf2 +m/-p (subsequently called Igf2ko) and Igf2 +m/+p (subsequently called ‘‘normal’’). ventolin 100 mcg Nonmanipulated Conceptuses To provide a baseline for the recombination experiments, … Continue reading

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