Category Archives: Fatal aplastic

Fatal aplastic anemia associated with ticlopidine therapy – Approaches to an adverse drug reaction: CONCLUSIONS

Calculation of posterior probability: The posterior odds equal the product of the prior odds and each of the likelihood ratios (2.73x1x3.71x1x1x1=10.1). The posterior probability equals the post erior odds over (1 + the post erior odds), ie, 10.1/ (1+10.1). The … Continue reading

Fatal aplastic anemia associated with ticlopidine therapy – Approaches to an adverse drug reaction:COMMENTS(3)

More rigorous diagnostic aids might therefore be helpful in defining a likelihood. In particular, standardized decision algorithms such as the adr Probability Scale (aps), a questionnaire with a pre-set weighted scoring system for specific case features, have increased interrater reliability … Continue reading

Fatal aplastic anemia associated with ticlopidine therapy – Approaches to an adverse drug reaction: COMMENTS(2)

Differential diagnoses: For aplastic anemia, nondrug causes could include viral infections, paroxysmal nocturnal hemoglobinuria, malignancies, immune disorders, other toxins and idiopathic marrow failure. There were no clinical or laboratory features to support these etiologies. Literature review: Six cases of aplastic … Continue reading

Fatal aplastic anemia associated with ticlopidine therapy – Approaches to an adverse drug reaction: COMMENTS(1)

COMMENTS Adverse drug events are a common occurrence in clinical practice. The main issue that arises when analyzing suspected adverse drug reactions (adrs) is the degree of certainty over whether the drug is in fact responsible. Most physicians instinctively ar … Continue reading

Fatal aplastic anemia associated with ticlopidine therapy – Approaches to an adverse drug reaction: CASE DESCRIPTION

CASE DESCRIPTION A 71-year-old woman with transient ischemic attacks was prescribed ticlopidine 250 mg bid. Her past history included hypertension and hypothyroidism, treated for the previous four years with nifedipine and L-th yro xine. Blood counts at baseline were normal. … Continue reading