Category Archives: Emphysema

Advanced Emphysema in African-American and White Patients: Conclusion

The percentage difference in emphysema severity and distribution between the two groups, based on quantitative CT analysis (Table 5, Fig 4), suggests some variability in lung response to injury caused by smoking, and thus supports the notion of differences in … Continue reading

Advanced Emphysema in African-American and White Patients: Discussion

Socioeconomic status is another aspect that may have a significant confounding effect on the prevalence of emphysema. This aspect is difficult to control for because it entrains access to health care, level of education, environmental exposure, and possibly respiratory infections. … Continue reading

Advanced Emphysema in African-American and White Patients: Discussion

Few doubt that the answer lies in the complex genotype/environment interactions, but the extent to which each factor plays in the pathogenesis of emphysema is enigmatic. Except for a1-antitryp-sin deficiency, no studies have identified other “emphysema genes” that distinguish the … Continue reading

Advanced Emphysema in African-American and White Patients: Results

In white patients, the core-peel difference was significantly greater in the lung apex but not at the mid and basilar lung regions than in the African-American patients. In Figure 4, the frequency distribution of the core-peel percentage of emphysema differences … Continue reading

Advanced Emphysema in African-American and White Patients: Demographic and Physiologic Racial Differences

Between January 1998 and July 2002, a total of 1,218 patients with severe emphysema were enrolled in the NETT. Forty-two of the patients (3.4%) were African American, and 1,156 patients (95%) were white. The baseline characteristics of these patients are … Continue reading

Advanced Emphysema in African-American and White Patients: Statistical Analysis

In addition to the density histogram, the a value (the negative slope) from the log-log relationship of hole size vs percentage of holes (with hole membership defined as voxels at — 950 HU, — 910 HU, or — 850 HU) … Continue reading

Advanced Emphysema in African-American and White Patients: Patient Data

The initial evaluation included 6-min walk distance; post-bronchodilator pulmonary function tests; maximal exercise capacity during cycle ergometry while receiving 30% oxygen; echocardiography; radionuclide pharmacologic (dobutamine) cardiac stress testing; arterial blood gas measurement; and lung perfusion scanning. Patients also responded to … Continue reading

Advanced Emphysema in African-American and White Patients: Patient Selection

In this study, we sought to separate the confounding effects of smoking behavior on severity of lung disease in African-American and white patients, and examined the association between race and the extent of emphysema in a specific, well-defined patient population: … Continue reading

Advanced Emphysema in African-American and White Patients

The prevalence of COPD is known to be different between African Americans and whites. Murphy et al and Massaro et al were the first to suggest that COPD is a disease of white men rather than African Americans. Large epidemiologic … Continue reading