Category Archives: Cardiology

Acute Reversible Cardiomyopathy Associated With the Systemic Inflammatory Response Syndrome – Discussion

This patient demonstrated a severe, acute reversible abnormality of myocardial function, the cause of which is not clear. Marked improvement occurred, temporally related to the removal of her necrotic remnant kidney. Sepsis has been demonstrated to be associated with decreased … Continue reading

Acute Reversible Cardiomyopathy Associated With the Systemic Inflammatory Response Syndrome – Results

By the fifth postoperative day, she was noted to have a temperature of 38.5°C with an elevated white blood cell count of 14.4 xl09/L. A persistent sinus tachycardia (150/min) was present with a summation gallop and apical pansystolic murmur on … Continue reading

Acute Reversible Cardiomyopathy Associated With the Systemic Inflammatory Response Syndrome – Case Report

Severe acute reversible myocardial dysfunction without ischemic heart disease is a relatively uncommon clinical entity. In the ICU, sepsis is often implicated, related perhaps to cytokines such as tumor necrosis factor (TNF) and interleukin 2. Although not widely recognized, a … Continue reading

Transcellular synthesis of cysteinyl-leukotrienes: From isolated cells to complex organ system (part 4)

Permanent ligation of the left descending artery resulted in significant mortality (65%) over the three days of observation, particularly during the first 24 h (45%). Pretreatment with BAY X1005 was life saving during the first 24 h after ligation (no … Continue reading

Transcellular synthesis of cysteinyl-leukotrienes: From isolated cells to complex organ system (part 3)

Male albino New Zealand rabbits, under anesthesia and artificial respiration, were opened on the left side of the thorax, and the small branch of the left anterior descending coronary artery was separated from the myocardial tissue for a length of … Continue reading

Transcellular synthesis of cysteinyl-leukotrienes: From isolated cells to complex organ system (part 2)

During the past five years we developed and characterized a model of spontaneously beating, isolated rabbit heart, perfused with purified human PMNL, showing that PMNL activation causes cys-LT formation through PMNL-endothelial cell transcellular synthesis, resulting in increased coronary resistance and … Continue reading

Transcellular synthesis of cysteinyl-leukotrienes: From isolated cells to complex organ system (part 1)

Cysteinyl-leukotriene (Cys-LT) formation either may proceed through activation of a single cell type, possessing both 5-lipoxygenase and leukotriene (LT) C4 synthase enzymatic activities (direct synthesis), or it may involve the participation of different cell types whereby donor cells (ie, polymorphonuclear … Continue reading

Comparison of disopyramide, propafenone and sotalol after direct current cardioversion of chronic atrial fibrillation (part 9)

  Class Ia and III drugs may be effective if the arrhythmia depends on shortening of refractoriness. Class Ic drugs may act by suppressing arrhythmogenic premature beats or by rate-dependent prolongation of refractoriness. Crijns et al suggested that such a … Continue reading

Comparison of disopyramide, propafenone and sotalol after direct current cardioversion of chronic atrial fibrillation (part 8)

Karlsson and coworkers randomized 44 patients to di-sopyramide and 46 to placebo in a double-blind multicentre study. The most common diagnosis in both groups was lone AF. After one year, 30% of patients in the placebo group and 54% in … Continue reading

Comparison of disopyramide, propafenone and sotalol after direct current cardioversion of chronic atrial fibrillation (part 7)

DISCUSSION Despite a variety of available therapeutic strategies, maintenance of normal sinus rhythm after cardioversion from AF has remained an unresolved problem. The present study was undertaken to compare the efficacy and safety of disopyramide, propafenone and sotalol, which are … Continue reading

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