Category Archives: Asthma

Effects of Early Intervention With Inhaled Budesonide on Lung Function in Newly Diagnosed Asthma: Summary

The contribution of bias must be considered when interpreting the results of this study. Two potential sources of bias exist. These are as a result of the study design and in the calculation of the predicted normal values. The trial … Continue reading

Effects of Early Intervention With Inhaled Budesonide on Lung Function in Newly Diagnosed Asthma: Recommendation

The decline demonstrated a Gaussian-like distribution in both treatment groups but with fewer patients in the budes-onide group in the tail with a greater loss in FEV1. Thus, 21.4% of patients in the placebo group had a decline in FEV1 … Continue reading

Effects of Early Intervention With Inhaled Budesonide on Lung Function in Newly Diagnosed Asthma: Comment

A surprising result of this study was that no significant effect was demonstrated in adolescents on prebronchodilator or postbronchodilator FEV1 over the 3 years of the study. This result was similar to that described in the CAMP trial, which contained … Continue reading

Effects of Early Intervention With Inhaled Budesonide on Lung Function in Newly Diagnosed Asthma: Conclusion

The prebronchodilator FEV1 value improved in both the placebo- and budesonide-treated populations but significantly more so with budesonide treatment. The beneficial effect of budesonide is consistent with many previous studies demonstrating an improvement in prebronchodilator FEV1 over time with inhaled … Continue reading

Effects of Early Intervention With Inhaled Budesonide on Lung Function in Newly Diagnosed Asthma: Discussion

This study is the first large, prospective evaluation of the effects of early intervention with inhaled corticosteroids on asthma progression, as determined by the development of severe asthma-related events and changes in lung function. In this study, average duration of … Continue reading

Effects of Early Intervention With Inhaled Budesonide on Lung Function in Newly Diagnosed Asthma: Research

The change in postbronchodilator FEV1 in the treatment groups demonstrated a Gaussian-like distribution (Fig 2), and the decline was more marked for males, current, or previous smokers, and patients > 18 years old. In the placebo group over years, the … Continue reading

Effects of Early Intervention With Inhaled Budesonide on Lung Function in Newly Diagnosed Asthma: Results

Of the 7,241 patients that entered the study, 7,165 were available for analysis, of whom 3,597 were randomized to budesonide and 3,568 to placebo. From this cohort, 2,010 patients did not complete the 3 years of double-blind treatment. The dropout … Continue reading

Effects of Early Intervention With Inhaled Budesonide on Lung Function in Newly Diagnosed Asthma: Statistical Methods

The FVC values are only reported for adults because children often failed to complete the FVC maneuver correctly. Spirometry was performed (MicroLoop II; Micro Medical; Rochester, UK). The postbronchodilator FEV1 was measured at randomization, after 6 and 12 weeks, and … Continue reading

Effects of Early Intervention With Inhaled Budesonide on Lung Function in Newly Diagnosed Asthma: Materials and Methods

The effectiveness of early intervention of inhaled corticosteroids on asthma progression has yet to be established in recent-onset, persistent disease. Therefore, a large worldwide, long-term, doubleblind, placebo-controlled comparison of low doses of inhaled corticosteroids initiated within the first 2 years … Continue reading

Effects of Early Intervention With Inhaled Budesonide on Lung Function in Newly Diagnosed Asthma

Asthma is identified by the presence of reversible airflow obstruction; however, irreversible airflow obstruction also develops in some asthmatic patients. Peat et al described a greater decline in lung function, as measured by height-adjusted FEV1, in a cohort of asthmatic … Continue reading

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