Caspase-3 in the Rat Ovary: DISCUSSION(7)


Theca cells are the major site of LDL uptake and cholesterol synthesis in the follicle and are therefore likely to contain SREBP. However, the presence of this transcription factor in theca cells has not yet been reported. ventolin inhaler

The recent evidence pointing to the role of caspases in activating DNA degradation suggests that in order for ovarian cells to complete the apoptotic program they must contain caspase-3, DFF, and an endogenous nuclear DNase. We have previously demonstrated that granulosa and luteal cells contain endogenous nuclear DNase I, and we hypothesized that these cells would therefore only require a signal to activate this enzyme in order to degrade their DNA in an apoptotic fashion. However, the present findings of endogenous caspase-3 in luteal but not granulosa cells suggests that the former might only require a signal to initiate DNA degradation, while the latter would require both caspase-3 expression and a signal for this to occur. A complete understanding of the regulation of DNA degradation during ovarian follicular atresia and luteal regression will require the study of DFF as well as the investigation of the

regulation of DNase I, caspase-3, and DFF expression during apoptosis in the ovary.

This entry was posted in Luteal Regression and tagged Caspase, Follicular Atresia, Rat Ovary.