Results of the present study also suggest that ovarian thecal cells have high-affinity receptors for leptin. Comparison of the DNA sequence of the bovine leptin receptor with that of the human and mouse indicates a 81% and 75% sequence identity, respectively. This suggests that the leptin receptor, like leptin itself, may be noticeably conserved across species. Although leptin receptors have not been previously identified in thecal cells of any species, the leptin receptor and(or) its mRNA has been identified in other murine and human endocrine tissues. Moreover, leptin receptor mRNA has been recently identified in adult human testis and ovarian tissue . In fact, human ovarian tissue had greater amounts of leptin receptor mRNA than most tissues that were evaluated . Therefore, the present and previous studies indicate that the bovine and human ovary are likely target organs for leptin. Because a significant proportion of women with polycystic ovarian disease have elevated serum leptin when compared to women exhibiting normal menstrual cycles , perhaps leptin plays a role in the clinical manifestation of infertility in women with polycystic ovary disease. Further research will be required to verify this suggestion. buy levaquin online
In conclusion, the results of the present study indicate that leptin, at physiologic concentrations, directly affects steroidogenesis of thecal cells. We suggest that normally fluctuating concentrations of leptin in blood may play an important role in communicating the metabolic status of the animal to the reproductive system.